CBD and Drug Interactions

CBD Drug Interactions

There are certain drugs that interact with Cannabidiol, these interactions typically involve drugs that are metabolized by CYP450 enzymes and could possibly interact with CBD. Indiana University Department of Medicine reports that drugs known to use the CYP450 system include:

HIV antivirals ᛫ Immune modulators ᛫ Benzodiazepines ᛫ Steroids ᛫ Anti-epileptics ᛫ Beta blockers ᛫ PPIs ᛫ Antidepressants ᛫ NSAIDs ᛫ Angiotension II blockers ᛫ Oral hypoglycemic agents ᛫ Sulfonylureas ᛫ HMG CoA reductase inhibitors ᛫ Calcium channel blockers ᛫ Antihistamines ᛫ Prokinetics ᛫ Anti-arrythmics ᛫ Antibiotics ᛫ Anesthetics ᛫ Anti-psychotics 

The drugs that interact with CBD is not limited to the medications above. It is advised that anyone who considers using CBD should firstly consult with a Doctor or Medical Professional.

Further Reading:

A Review of Clinical Data on the Side Effects and Interactions of Cannabidiol

The Grapefruit Test

This is actually a great trick if you want to know if any of your medications will interact with cannabidiol. Do the “Grapefruit Test” with your physician. The “grapefruit test” is asking your doctor if any of the drugs you’re taking are affected by eating grapefruits. CBD words similarly to grapefruit… it can impact many drugs that are widely used. CBD acts in precisely the exact same manner chemically as a grapefruit, just more powerful.

When talking to your doctor, your doctor might not know about CBD… therefore a safe second option when discussing using CBD is to ask if any of your medications can interact with grapefruit.

Can you Drink Alcohol and CBD?

One of the most popular questions in regards to CBD drug interactions is whether or not someone who suppliments with CBD can drink alcohol during one’s dosing with CBD. Unfortunately research hasn’t gone far enough to answer that question for us. It is important that one is cautious when drinking alcohol white taking CBD.

Never the less we do know a thing or two about CBD and Alcohol interactions:

Those taking CBD typically have a lower blood level of alcohol when taking CBD when compared to a controlled group. CBD also reduces the the brain mechanisms which are responsible for cravings for relapse to alcohol on any degree.

As research continues we will further update our knowledge-base with relevant information for CBD and Alcohol interactions

Can you Drink Caffeine and CBD?

CBD and Caffeine? A better couple than coffee and cream! They actually complement each other so nicely! CBD actually binds to the same receptor as caffeine! Typically when we get tired, a hormone in our brain (called Adenosine) binds to a certain receptor called A2a. When that happens, that results in a “Digest and Rest” effect. The human body gets a signal to rest in order to facilitate digestion. Caffeine blocks that very receptor in order to upkeep energy and vitality. Surprisingly CBD binds to that same receptor and facilitates caffeine in the same way. At the same time, while blocking the A2a receptor it also slows down the absorption of caffeine which results in a prolonged effect!

One should be cautioned that this may enable one to drink more coffee throughout the day without the perils of anxiety which may result in staying up all night.