20% of people with major depressive disorder develop psychotic symptoms. 10-15% of women develop postpartum depression. Depression affects over 350 million people worldwide. Women are more likely to be diagnosed with depression than men. When it comes to treating depression the options are unfortunately extremely limited.

According to the National Institute of Mental Health, “treating depression involves many moving parts, only one of which is antidepressants. And a person’s response to them is dependent on many factors.” A 2010 study concluded that “CBD induces antidepressant-like effects comparable to those of Imipramine.

These effects of CBD were probably mediated by activation of 5-HT(1A) receptors.” A 2014 study found that “Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound.”

A 2016 study reported, “our results demonstrate that CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia.”

Depression Studies